On July 19, 2022, it was announced that sales of Fates would cease on February 28, 2023, ahead of the Nintendo eShop's closure on March 27, 2023. Upon release, it met with highly positive reviews: Birthright was generally seen as a good starting place for new players, Conquest was praised for its challenge, while Revelation was noted as a good middle ground between the two releases. To show all sides of the story and provide players with different Fire Emblem experiences, the game was split up into multiple versions. To this end, writer Shin Kibayashi was brought in. The team's main concern was adding new features and refinements to the original gameplay, and improving the story, which had received criticism from some fans. The gameplay, which revolves around tactical movement of units across a grid-based battlefield, shares many mechanics with previous Fire Emblem games, although some elements are unique to each scenario.Īfter the critical and commercial success of Awakening, development began on Fates, with the staff of Awakening returning to their previous roles. In Revelation, the Avatar rallies both sides against the true mastermind behind the war. The overarching story follows the protagonist, a customizable Avatar named Corrin by default, as they are unwillingly drawn into a war between the Kingdoms of Hoshido (their birthplace) and Nohr (their adopted home), and must choose which side to support. Unlike previous titles, Fates was released in three versions, each following a different storyline centered on the same characters: Birthright and Conquest as physical releases, and Revelation as downloadable content. It is the fourteenth installment in the Fire Emblem series and the second to be developed for Nintendo 3DS after Fire Emblem Awakening. It was released in June 2015 in Japan, then released internationally in 2016. Fire Emblem Fates is a tactical role-playing video game for the Nintendo 3DS handheld video game console, developed by Intelligent Systems and Nintendo SPD and published by Nintendo.
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So there you have it - just install a fireplace next to your hood (what every lab needs, for sure) and remember that, in a thioacetone situation, fogging the area with brown nitrogen oxide fumes will actually improve the air. "The offensive odors released by cracking trithioacetone to prepare linear poly(thioacetone) are confined and eliminated by working in a large glove box with an alkaline permanganate seal, decontaminating all apparatus with alkaline permanganate, eliminating obnoxious vapors with nitrous fumes generated by a few grams of Cu in HNO3, and destroying all residues by running them into the center of a wood fire in a brazier." How do you work with something that smells like hell's dumpster? Like this: Now that's a compound to be taken seriously. The odour was detected downwind in seconds." To convince them otherwise, they were dispersed with other observers around the laboratory, at distances up to a quarter of a mile, and one drop of either acetone gem-dithiol or the mother liquors from crude trithioacetone crystallisations were placed on a watch glass in a fume cupboard. and genuinely denied responsibility since they were working in closed systems. The odours defied the expected effects of dilution since workers in the laboratory did not find the odours intolerable. Two of our chemists who had done no more than investigate the cracking of minute amounts of trithioacetone found themselves the object of hostile stares in a restaurant and suffered the humiliation of having a waitress spray the area around them with a deodorant. During early experiments, a stopper jumped from a bottle of residues, and, although replaced at once, resulted in an immediate complaint of nausea and sickness from colleagues working in a building two hundred yards away. "Recently we found ourselves with an odour problem beyond our worst expectations. The most in-depth analysis took place at the Esso Research Station in Abingdon, UK, where Victor Burnop and Kenneth Latham got to experience the Freiburg Horror for themselves: The compound shows up sporadically in the literature until the mid-1960s, when several groups looked into thioketones as sources of new polymers. An 1890 report from the Whitehall Soap Works in Leeds refers to the odor as "fearful", and if you could smell anything through the ambient conditions in a Leeds soap factory in 1890, it must have been. This reaction produced "an offensive smell which spread rapidly over a great area of the town causing fainting, vomiting and a panic evacuation.". The canonical example ( Chemische Berichte 1889, 2593) is the early work in the German city of Freiburg in 1889 (see here), which quotes the first-hand report. There are sound historical reasons for this reluctance. No one's quite sure what the actual odorant is (perhaps the gem-dimercaptan?) And no one seems to have much desire to find out, either. Attempts to crack this to thioacetone monomer itself have been made - ah, but that's when people start diving out of windows and vomiting into wastebaskets, so the quality of the data starts to deteriorate. All we know for sure is that thioacetone doesn't like to exist as a free compound - it's usually tied up in a cyclic thioketal trimer, when it's around at all. It reeks to a degree that makes people suspect evil supernatural forces. It makes innocent downwind pedestrians stagger, clutch their stomachs, and flee in terror. But it does so relentlessly and unbearably. No, I will not work with such.īut today's compound makes no noise and leaves no wreckage. These are compounds that explode with bizarre violence even in laughably small amounts, leaving ruined equipment and shattered nerves in their wake. My recent entries in this category have, for the most part, been hazardous in a direct (not to say crude, or even vulgar) manner. Not only is the regal Lion the long-anticipated ruler, rising from the royal tribe of Judah, with the strength and power of heaven itself, but he is also the gentle, lowly, self-giving Lamb, who gladly lays down his own life that his people might live. Now heaven’s praises focus on this lamblike Lion of Judah, this lionlike Lamb who was slain. (5:9–10)Īt this moment, John hears the voices of tens of thousands of angels, too many to count, in what must have been an overwhelming chorus, declaring with one loud voice, “Worthy is the Lamb who was slain, to receive power and wealth and wisdom and might and honor and glory and blessing!” (5:12).įirst, the worship of heaven declared the worth of God Almighty. He takes the scroll from the hand of God Almighty.Īnd the four creatures and twenty-four elders of heaven, who had declared the worth of God Almighty, now fall down, singing a new song, to declare the worth of the Lamb:įor you were slain, and by your blood you ransomed people for Godįrom every tribe and language and people and nation,Īnd you have made them a kingdom and priests to our God,Īnd they shall reign on the earth. Like the “son of man,” the Lamb approaches the throne of heaven. John writes, “I saw a Lamb standing, as though it had been slain” - but not in weakness, but with great power: “with seven horns and with seven eyes” (5:6). One of the elders then turns to John to announce the good news: “Weep no more behold, the Lion of the tribe of Judah, the Root of David, has conquered, so that he can open the scroll and its seven seals” (5:5).įinally John’s vision unveils its single greatest detail, advancing the “son of man” prophecy in Daniel 7, and echoing Stephen’s shocking peek at heaven’s throne where Jesus stood. The apostle senses the drama, and tragedy, of the moment, and says, “I began to weep loudly because no one was found worthy to open the scroll or to look into it” (5:4). None is worthy for this critical task - not the four creatures, not the elders, not the angels, not any mere human. John’s commentary is striking: “And no one in heaven or on earth or under the earth was able to open the scroll or to look into it” (5:3). Such a scroll represents God’s will and purposes for all of history, to be executed upon its opening.Ī mighty angel, with a loud voice, asks, “Who is worthy to open the scroll and break its seals?” (5:2). John then sees a sealed scroll in the right hand of God. The four creatures declare him to be “Holy, holy, holy,” and the elders fall down in worship and “cast their crowns before the throne” and tell of God’s infinite value:Īnd by your will they existed and were created. There he saw “a throne stood in heaven, with one seated on the throne” (4:2), with twenty-four elders and four living creatures praising “the Lord God Almighty” (4:8). Jesus’s beloved disciple, exiled on the isle of Patmos, received a vision of “a door standing open in heaven” and heard the summons, “Come up here” (Revelation 4:1). Still, the greatest sight of heaven’s throne in all of Scripture was kept for the final book of the canon. Then, in Acts, after Christ’s ascension, the first Christian martyr, Stephen, looked into heaven and the saw the glory of God, with Jesus standing at his right hand (Acts 7:55). In perhaps the most revealing vision prior to the coming of Christ, the prophet Daniel, exiled in Babylon, saw the Ancient of Days on his throne, with an enigmatic figure called the “son of man” coming forward to receive power (Daniel 7:13–14). So too Ezekiel caught a glimpse of God on his chariot throne as he departed from Jerusalem (Ezekiel 1:26). Isaiah saw the Lord seated on his throne, with the hem of his garment filling the temple (Isaiah 6:1). Moses asked to see God’s glory on the mountain, and was given a glimpse of his trailing afterglow, while hiding in the cleft of the rock (Exodus 33:23). Jacob saw angels ascending and descending, with God standing above (Genesis 28:12–13). In a Book of stunning visions of God himself seated on the throne of heaven, none surpasses the one given to the apostle John in Revelation 4 and 5. Worthy is the Lamb who was slain, to receive power and wealth and wisdom and might and honor and glory and blessing! (Revelation 5:12) Thank you for your timely response.Īnother alternative you can use in place of I’m looking forward to hearing from you is I hope to hear from you soon. Dear Georgette,Ĭan you please forward the emails from the contractors? I need to review their proposals before proceeding. If time is of the essence, then this alternative best signals that a time-sensitive response is needed. Your prompt response would be appreciated. I need to know what the final estimate was. This I’m looking forward to hearing from you synonym is best reserved for colleagues, coworkers, or employees, not employers. Thank you for taking the time to interview me. This alternative expresses that you’re enthusiastic to receive a reply. Below, you’ll find five business-friendly alternatives you can use in place of I’m looking forward to hearing from you. Professional communication requires you to follow an appropriate standard. “I’m Looking Forward To Hearing From You ”: Business-Friendly Alternatives In other words, the message they carry isn’t as powerful as it should be.įor that reason, we’ve compiled a list of professional and casual alternatives you can use in place of I’m looking forward to hearing from you “I look forward to hearing from you” (and its variants) are regularly used in business communication. The only problem is that they are used so frequently, they often go unnoticed. There’s nothing technically wrong with using them in emails. The email expressions I look forward to hearing from you and I’m looking forward to hearing from you are direct and practical. I’m looking forward for hearing from you. However, be careful not to use the following variations, as they are incorrect. I’m looking forward to hearing from you.īoth are acceptable and both carry the same meanings.Perhaps you’ve come across two variations of this phrase: “I’m Looking Forward to Hearing From You” Thank you for letting me run these propositions by you. The phrase is found towards the end of emails. You’re hoping for a reply sooner rather than later.I’m looking forward to hearing from you is a phrase regularly used in email communication, especially in professional and academic settings. “I’m Looking Forward To Hearing From You” Meaning There are also a few casual alternatives you can use in place of I’m looking forward to hearing from you. Your prompt response would be appreciated.Business-friendly alternatives you can use instead include: I look forward to hearing from you is a standard email phrase often used in professional settings. “I’m Looking Forward To Hearing From You” Synonyms 4 Ways to Find Malware Using Windows Defender Scan If you're a Windows user who's stuck with expired third-party antivirus software or are planning to buy antivirus software, you don't have to. Ultrasonic Fingerprint Scanner vs Optical Fingerprint Scanner: How Do They Differ After big screens, if there is one thing that has evolved with smartphones is, the unlocking methods. You can never be too careful when it comes to online security threats. Online scanners like F-Secure are the not an umbrella solution, but just another ace you should have up your sleeve. There! You now have a clean system as well as some peace of mind. These files can be deleted from the system and send to F-Secure as a sample. You might have to twiddle your thumbs if your net speed is a turtle.īut once the scan is through, the application displays a summary targeting the harmful files. The only hitch with an online scanner is in the time it takes the F-Secure Scanner to download some necessary files from the internet. As the screen shows, F-Secure Online Scanner can also scan inside compressed files, and more importantly – you can enable it to detect malware exploits via rootkits. Clicking on Show Options gives you a few more choices to select. Of the three, I often like to use the My Scan mode to quickly scan any suspicious files I might have downloaded by mistake. The F-Secure Online Scanner gives you three scan modes. You can be assured of the latest virus definition updates as F-Secure maintains the same database across all its security products. The only thing you need to do is enable JavaScript, and you need to have at least Version 6 Update 10 of Java Runtime Environment installed. 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That’s less than half the burden of Windows’ own antivirus protections, which weigh in at 12.5%, so if you’re switching from Windows Security to F-Secure SAFE, you can expect a small but measurable performance boost. F-Secure incurs an impressively low 6.1% drag on overall system performance. In fact, when AV-Comparatives previously tested SAFE in September 2020, they gave it an excellent online protection rating of 99.99%, confirming its top-notch antivirus capabilities.Īs for speed, the figures speak for themselves. F-Secure SAFE wasn’t part of AV-Comparatives’ latest antivirus tests, so our numbers reflect AV-Test’s findings alone. Still, F-Secure SAFE ranks highly in the protection and performance stakes. It all adds up to a conspicuously short feature list. F-Secure SAFE review: How good is protection and performance? So far, Lizzy Wurst has over 4,000 subscribers on her OnlyFans account. 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The NHRA, in concert with professional nitro teams, has effectively instituted an “index” of late by diminishing the preparation of the racetrack to contain speeds. Can drag racing survive merely on side-by-side competition, of numbers people have seen before, and not on that of continual mechanical pursuit? Going faster is what it’s all about, pure and simple, and lest you believe otherwise, check out the spectator count at a bracket race sometime.ĭrag racing stands at a crossroads for a number of reasons, but one of those is that it’s on the verge of taking that element - that element which has captivated racers and fans as records and performance milestones have come and gone - out of the equation. If 87-year-old Chris Karamesines had decided back in the 1950’s that he was going to stop trying to go faster and just beat ‘em on the tree, he’d be about four-seconds slower than the Top Fuel field today. Fellow journalists may argue that numbers don’t matter - I would say they wholeheartedly do matter to the overwhelming majority of racers and fans - but even if you take away the numbers, this sport is nevertheless entirely about the never-ending pursuit of going quicker and faster. But drag racing has always been about the pursuit of greater performance - of showing people something they’re never seen before. Stock cars don’t necessarily need to go faster to continue being relevant, interesting, and entertaining baseball players don’t need to continually throw harder or hit further with each passing generation quarterbacks don’t have to score more touchdowns than previous stars to make the NFL popular. And it’s keeping us from asking the question: what are we doing to preserve the sport of drag racing for both ourselves and future generations?Īs an acceleration contest at its very core, drag racing is unique in the world of sports. I believe because we’re so fixated on the now, we are blind to the realization that drag racing is at or very near a defining time in its existence. As drag racers, we tend to operate in the present or in the relatively near-term we need FedEx to get that torque converter or set of tires here so we can go racing this weekend we’re pissed off that the supercharger combination in X275 didn’t get hit with enough weight this week we need that sponsor to get us to the next race the track prep this weekend isn’t to our standards and we can’t break the class record. For example, if the temperature is 18☌ and the relative humidity is 96%, an increase in the air temperature of only 2☌ reduces the relative humidity to 85%. The capacity of air to hold water vapor is dependent on temperature. The major drawback of using relative humidity is that it is heavily dependent on temperature. It is the ratio, expressed as a percentage, between the amount of water vapor present and the maximum amount that is physically possible at that temperature. Relative humidity is the most commonly used humidity measurement. Like wet-bulb temperature, dew point temperature is always less than or equal to the dry-bulb temperature. For use in cooling tower control systems, dew point temperature is the next best measurement to wet-bulb temperature since it measures a temperature where water is condensing (not vaporizing) and it correlates with the amount of water vapor in the air at that temperature. This is the temperature at which air becomes fully saturated with water vapor resulting in the formation of liquid water. Tower operators need to be able to answer the question ‘What is the wet-bulb temperature?’ If they can’t answer that question, they are not using the best measurement for their operations,” says Tim Wilcox, an international energy efficiency consultant with U.S.-based WPIĭew point is the temperature where condensation begins. “Cooling towers are designed to operate to a range of wet-bulb temperatures in a certain location. Wet-bulb temperature is always less than or equal to the dry-bulb, or ambient air, temperature. Outdoor wet-bulb temperature is the lowest temperature that can be achieved purely by evaporative cooling and is the lowest possible temperature of the process water leaving the tower. Cooling tower controls are based on a single lower-limit set point, outdoor wetbulb temperature.Įvaporative cooling benefits cease when a combination of environmental variables – relative humidity, water vapor saturation pressure, and temperature – reach a point where liquid water cannot vaporize into the air. The most common set points for HVAC systems are specified upper and lower limits of temperature and humidity. Like the rest of the HVAC system, the cooling tower is operated by a control system that uses set points to govern operations. A cooling tower with an automated control system is designed to operate at peak efficiency, minimizing these operational costs and reducing maintenance and repair costs to fan and pump equipment. Condenser water lost to evaporation needs to be replaced and energy is consumed to run the tower’s fans and pumps. Water and energy use are two operational cost drivers of a cooling tower. The cooled condenser water is returned to the chiller to accept heat again from the refrigerant. The heated condenser water is circulated out of the chiller to a cooling tower, where it is distributed onto complex porous surfaces and exposed to increased air flow provided by fans to maximize evaporation and remove heat from the water. The waste heat must be removed from the condenser water before it can accept more heat from the refrigerant. In the chiller, there is an exchange of heat from the refrigerant to the This exchange cools the refrigerant and heats the condenser water. The function of the cooling tower is to remove heat from the process fluids, in this case from the condenser water used to cool the refrigerant in the chiller unit of the HVAC system. Shortcomings in any of these areas can result in cooling tower overuse, which leads to increased water and energy usage and reduces the functional life of fans and pumps. When evaporative cooling can occur is based on local environmental variables that can be provided by one measurement: outdoor wet-bulb temperature.Ĭooling towers can be operated for peak efficiency under the following conditions: outdoor wet-bulb temperature is used as the basis for the control system set point, measurement instruments are accurate and reliable, and operators routinely check instruments for sensor drift. Outdoor Wet-bulb Temperature – The Defining Measurement for Cooling Tower OperationsĬooling towers are used as part of industrial HVAC systems to remove heat from process water by evaporative cooling. To turn off automatic app updates, go to Settings > App Store and turn App Updates off. Update apps manually when the battery is fully charged, but otherwise, turn off automatic app updates. This is a convenience and a battery drainer. The NSO Spyware group's Pegasus malware is a particularly nasty example, but these kinds of hacks are generally reserved for those nation states consider to be high value targets. In iOS 7 or newer, disable the feature that automatically updates apps as new versions are released. That's why these pricey hacks are often kept under wraps by the people, or governments, who purchase them, Green says. The minute the world knows, it's only a matter of time before the hack is obsolete. The bugs are known as "zero-day" exploits, corresponding with the fact that Apple will find out about a possible security issue in their software on the same day it'll work to patch it. "If it's someone who is really sophisticated, they'll send you an invisible text message and then your phone is going to be compromised for awhile." "This is a very sophisticated set of hacks and oftentimes you won't even know this happened to you," Green says. Apples iOS 14.6 brought new features and bug fixes to your iPhone, but users are reporting a problem with battery life. With this knowledge, hackers can install malware to get data from targeted sources. The tweak is super useful for people who always have the battery case on and want to know how much juice is left on their device before they. News: Apple Releases iOS 13.4 Developer Beta 5 for iPhone News: iOS 11.2.6 Released for iPhones with Patch for Telugu Character Bug News: Apple iOS 11. Get your iPhone run longer on a single charge. One form of a targeted hack works like this: Hackers exploit unknown flaws in the iOS programming that even its developers don't yet know about. The new tweak for jailbroken iOS devices simply combines the battery percentages of the iPhone’s battery and the case, and shows a combined total percentage of remaining battery life in the status bar. Know the best battery tips for iOS, never run out of iPhone battery by using these simple battery saver hacks. It can help you find bad chargers and cables, check wired and wireless chargers, and provides other system information. Monitor battery level, get notification on reaching the desired battery charge level Amperes is an ultimate battery and charger testing app. Journalists and activists are most at risk for this kind of hack. Compare different chargers, wires, power banks. Keep your devices in check Locate your devices on a map Estimate distance to a device Keep a persistent log of device location history Check device battery and signal strength Track your physical activity: step count distance walked track calories burned. The average person probably won't be singled out and remotely targeted by hackers because it's expensive, sometimes costing millions for hacks of newer phones, says Matthew Green, an associate professor at the Johns Hopkins Internet Security Institute. Download HEADPHONES: BLUETOOTH FINDER and enjoy it on your iPhone, iPad and iPod touch. Numerous approaches are under investigation to increase CAR T-cell efficacy in solid tumor settings, reduce CAR T-cell relapse rates, and reduce the toxicity associated with CAR T-cell therapy. This study highlights the potential of G 4S-displaying CAR T cells to be redirected to engage alternative tumor-associated antigens (TAA). The cytolytic activity of CAR T-cells was redirected to different tumor antigens by changing the BsAb in a dose-dependent manner. We demonstrated that the BsAb can bridge CAR T cells to tumor cells and potentiate CAR T-cell activation, proliferation, and tumor cell cytolysis. Herein, we described a novel CAR T-cell adapter platform that relies on a bispecific antibody (BsAb) targeting both a tumor antigen and the GGGGS (G 4S) linker commonly used in single-chain Fv (ScFv) domains expressed on CAR T-cell surfaces. Adapter CARs allow simultaneous or sequential targeting of multiple tumor antigens, control of immune synapse geometry, dose control, and the potential for improved safety. To address this limitation and to add a further level of tunability and control to CAR T-cell therapies, adapter or universal CAR T-cell approaches use a soluble mediator to bridge CAR T cells with tumor cells. Nevertheless, the occurrence of relapse due to antigen escape or heterogeneous antigen expression on tumors remains a challenge for first-generation CAR T-cell therapies as only a single tumor antigen can be targeted. Tell a Story day is here! Here is the conclusion to the super-exciting interactive story that we wrote together.The success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies has altered the treatment paradigm for patients with these diseases.
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